This can be countered to an extent. You can increase the dosage towards the middle and later parts of taking it to increase the positive effects. You can also take a period of time away from the drug, cycling off for a bit to give your body time to recover before getting back to it again. Be aware that the more you take a day, the less results you will get added to through the additional dosage. So for example, taking 50mg a day adds a lot. Adding 50mg a day improves the results, but not by much. Adding 50mg more for 150mg a day adds slightly more, but it is typically not worth the negative side effects to your health for only marginal improvements. Studies conducted on the drug helps to back up this assertion, postulating that 100mgs/day is perfect for Anadrol cycling.
Oxymetholone (also known as anapolon or anadrol) is a very drastic synthetic steroid, 17-alpha-alkylated modification of dihydrotestosterone. It was developed for the treatment of osteoporosis and anaemia, as well as to stimulate muscle gain in malnourished and debilitated patients. Oxymetholone has been approved by the American Food and Drug Administration (FDA) for use in humans. Later there where created non-steroidal drugs that effectively could treat anaemia and osteoporosis; because of this anapolon lost his popularity and by 1993 Syntex decided to cease the production of the drug, as well as other manufacturers did.