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In general it has been found that oral steroids are more likely to prove detrimental to cardiovascular health than injectable forms of non C-17 alkyl steroids. In this regard it is important to point out that estrogen is actually known to have a positive effect on cholesterol levels, enhancing HDL levels, and keeping LDL levels under control. It is when aromatase inhibitors in ancillary compounds come into play during the steroid cycles that the individual is at risk of cardio-vascular diseases owing to estrogen levels being subdued. Further, it has been seen that when the individual is committed to a healthy diet that supports desired cholesterol levels during the steroid cycle , the risk of cardiovascular disease arising from steroid use can be kept under control.
Testosterone can be administered parenterally , but it has more irregular prolonged absorption time and greater activity in muscle in enanthate , undecanoate , or cypionate ester form. These derivatives are hydrolyzed to release free testosterone at the site of injection; absorption rate (and thus injection schedule) varies among different esters, but medical injections are normally done anywhere between semi-weekly to once every 12 weeks. A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system.  Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream. In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.