However, in December 2004 the United States the 14-member Food and Drug Administration (FDA) advisory committee, plus voting consultants, for Reproductive Health Drugs unanimously rejected Procter and Gamble's fast-track request for Intrinsa citing concerns about off-label use . In Canada, post-menopausal women have been able to obtain government-approved testosterone treatment since 2002. In Australia, post-menopausal women can use Organon testosterone implants which have to be surgically inserted and last from three to six months. 
Interaction with other drugs
Aspirin increases the toxicity of methotrexate, narcotic analgesics, other NSAIDs, oral hypoglycemic agents, heparin, anticoagulants, thrombolytics and angibitorov platelet aggregation, sulfonamides (in ), triiodothyronine; reduced -. uricosuric drugs (benzbromaron, sulfinpyrazone), antihypertensives and diuretics (. spironolactone furosemide)
Glucocorticosteroids, alcohol and alcohol-containing medications increase the damaging effect on the gastrointestinal methenolone enanthate mucosa, increase the risk of gastrointestinal bleeding.
Aspirin increases the concentration of digoxin, barbiturates and lithium plasma preparations.
Antacids containing magnesium and / or aluminum hydroxide, slow and reduce the absorption of acetylsalicylic acid.
Reduces the effectiveness of uricosuric drugs, increases the effects of anticoagulants, antiplatelet agents, fibrinolytic agents, ethanol, and the side effects of glucocorticosteroids mineralokortikosteroidov, estrogen; reduces the effectiveness of antihypertensive drugs and diuretics.
The joint reception with others. Primobolan dosage, corticosteroids, ethanol, corticotropin may lead to ulceration and the development of gastro-intestinal bleeding, an increase in the risk of impairment of renal function.
Co-administration with oral anticoagulants, heparin, thrombolytics, antiplatelet, cefoperazone, cefamandole and tsefotetanom increases the risk of bleeding.
It increases the hypoglycemic effect of insulin and oral hypoglycemic drugs (requires recalculation of the dose).
Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.
Co-administration with sodium valproate causes a disturbance of platelet aggregation.
Increases plasma concentration of nifedipine and verapamil, lithium, drugs, methotrexate.
antacids and cholestyramine reduce the absorption.
Myelotoxic drugs increase the expression gematotoksichnosti drug.
pharmaceutical incompatible with a solution of tramadol.