The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.
Given the positive impact of corticosteroids and progestational agents on cancer anorexia and cachexia and the fact that many patients with advanced cancer die with, and/or of, inanition, the potential prophylactic use of these agents was evaluated. A double-blind trial was conducted in which patients with newly diagnosed, extensive-stage small-cell lung cancer were randomized to receive megestrol or placebo along with standard chemoradiation therapy. This trial was unable to demonstrate any beneficial effect of megestrol on treatment response, quality of life, or survival.