AB - Introduction: Severe burn causes a hypermetabolic, catabolic state. Loss of body protein, mainly from muscle, causes weakness, impaired immune function and delayed healing. Oxandrolone is an oral steroid that has been used in cachectic cancer and AIDS patients as well as rehabilitating burn patients to restore muscle mass. We hypothesize oxandrolone may reverse muscle catabolism in cachectic, critically ill burn patients. Methods: Ten severely burned children were enrolled in a prospective cohort analytic series. All had received care without skin grafting at outside hospitals prior to transfer to our pediatric burn unit. Upon transfer, excision and grafting and nutritional supplementation were employed. Nutritional status was assessed by weekly prealbumin measurements. Muscle protein kinetics were determined using a stable phenylalanine isotope tracer. Initial studies were done 5-7 days after admission. Six subjects were studied before and after approximately 1 week of oxandrolone mg/kg QD. Four subjects were used as time controls and studied at matched time points. T-tests were used for statistical comparison. Data are presented as mean±SEM. Results: The four time control and six oxandrolone subjects did not differ in age or TBSA burn (±3 yrs vs. ± yrs; 40±5% vs. 41±11%). The control group arrived 34±17 days after injury, and the oxandrolone group 25±5. Prealbumin levels were low on presentation in both groups (± mg/dl control vs. ± oxandrolone) and remained low after one week of standard enteral feeding (14± vs. ±) with no differences between groups. Muscle protein net balance improved 1±6 nmol PHE/min/100cc leg in controls vs. 67±18 in the oxandrolone group (p<). The improved protein metabolism in oxandrolone subjects was accompanied by an increased protein synthetic efficiency determined by the percent of intracellular amino acids directed to protein synthesis (17±6% before, 37±5% after oxandrolone; p=). Muscle protein breakdown was unchanged. Conclusion: In cachectic, critically ill burn victims, oxandrolone improves net muscle protein synthesis by increasing the efficiency of intracellular amino acid utilization.
presents you another cutting cycle for summer which will make you look hard and solid. As a base we will use testosterone enanthate however you may replace it with testosterone propionate as in some individuals enanthate will make visible water retention but I dont think this is a problem as you dont prepare for the contest, right? 🙂 On the other hand switching to propionate will bring you another headache as you will have to inject it EOD plus you will inject Primobolan ( Methenolone Enanthate) 2-3 times per week so having to inject primo and test propionate will keep you really busy and will not give your injection sites enough time to rest.
I’m on TRT myself what is a good test level to read that 800 is optimal for muscle developing is that accurate . What is your test level on TRT? Do you use arimadex during TRT or just when you doing a cycle .
My doctor won’t give me HGC but I can get it . How much and how opten do you use it ? Do you use it during a cycle or in between cycles . What do you recommend for oily skin and zits on my back from the test. You mention that you give blood often can you explain that in more detail. Thank you very much this is the best site I’ve come across I appreciate your honesty.